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MIDSCI Inc battery-operated spinning homogenizer
Battery Operated Spinning Homogenizer, supplied by MIDSCI Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/battery-operated+spinning+homogenizer/battery+operated+spinning+homogenizer/pmc04499058-283-106-108
Average 90 stars, based on 1 article reviews
battery-operated spinning homogenizer - by Bioz Stars, 2026-09
90/100 stars

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Spectrophotometry:

Article Title: A 3D human neural cell culture system for modeling Alzheimer’s disease
Article Snippet: 1121-3810, 1120-1810, 1120-8810 and 1126-7810, respectively) RNase-free micro-centrifuge tubes (1.5 ml size; USA Scientific, cat. no. 1615-5500) PTC-200 Thermal Cycler (MJ Research, cat. no. ALD-1244) iCycler iQ TM (Bio-rad, cat. no. 170-8740) Bio-rad Tetrad® 2 Thermal Cycler (Bio-rad, cat. no. PTC-0240G with ALS-1296GC) NanoDrop 1000 Spectrophotometer (Thermo Scientific, cat. no. ND-1000) Bio-rad ChemiDoc XRS System (Bio-rad, cat. no. 170-8070) Immunofluorescence and Immunohistochemistry list-behavior=unordered prefix-word= mark-type=disc max-label-size=0 Olympus IX7 fluorescence microscope equipped with spinning disk confocal unit (Olympus) LSM Pascal 5 Carl Zeiss confocal microscope (Zeiss) Biochemical Extraction and Western Blot list-behavior=unordered prefix-word= mark-type=disc max-label-size=0 Hoefer Semi-Dry Transfer Unit (Hoefer, TE77) Molecular imager (Bio-rad, VersaDoc MP4000) Battery-operated spinning homogenizer (MIDSCI, cat. no. A0001) Ultracentrifuge tubes (Beckman Coulter, cat. no. 343778) Ultracentrifuge (Beckman, Optima TL Ultracentrifuge) SpeedVac (Thermo Scientific, cat. no. SPD111V) Savant RVT4104 refrigerated vapor trap with Savant SC110 SpeedVac (Savant) TEM list-behavior=unordered prefix-word= mark-type=disc max-label-size=0 JEOL JEM 1011 transmission electron microscope (JEOL) AMT digital imaging system (Advanced Microscopy Techniques) ELISA list-behavior=unordered prefix-word= mark-type=disc max-label-size=0 ELISA plate reader (Bio-Tek Synergy 2 microplate reader) LDH list-behavior=unordered prefix-word= mark-type=disc max-label-size=0 ELISA plate reader (Bio-Tek Synergy 2 microplate reader)

Article Title: A three-dimensional human neural cell culture model of Alzheimer’s disease
Article Snippet: Differential detergent extraction for WB The thick-layer 3D cultures of ReN cells were homogenized with TBS extraction buffer containing 50 mM Tris (pH 7.4), 150 mM NaCl, 1 mM NaVO 3 , 1 mM NaF, a protease inhibitor mixture (Roche Molecular Biochemicals), a phosphatase inhibitor cocktail (Thermo Scientific,), 2 mM PNT (EMD Millipore) and 1 mM Phenylmethylsulfonyl fluoride (PMSF, Sigma-Aldrich) by using battery-operated spinning homogenizer (MIDSCI, St. Louis, MO, USA).

Article Title: A 3D human neural cell culture system for modeling Alzheimer's disease
Article Snippet: 1121-3810, 1120-1810, 1120-8810 and 1126-7810, respectively) RNase-free microcentrifuge tubes (1.5 ml size; USA Scientific, cat. no. 1615-5500) PTC-200 thermal cycler (MJ Research, cat. no. ALD-1244) iCycler iQ (Bio-Rad, cat. no. 170-8740) Bio-Rad Tetrad 2 thermal cycler (Bio-Rad, cat. no. PTC-0240G with ALS-1296GC) NanoDrop 1000 spectrophotometer (Thermo Scientific, cat. no. ND-1000) Bio-Rad ChemiDoc XRS system (Bio-Rad, cat. no. 170-8070) IF and immunohistochemistry Olympus IX7 fluorescence microscope equipped with a spinning disk confocal unit (Olympus) LSM Pascal 5 Carl Zeiss confocal microscope (Zeiss) Biochemical extraction and western blotting Hoefer semi-dry transfer unit (Hoefer, TE77) Molecular imager (Bio-Rad, VersaDoc MP4000) Battery-operated spinning homogenizer (MIDSCI, cat. no. A0001) Ultracentrifuge tubes (Beckman Coulter, cat. no. 343778) • • • • • • • • • • • • • • • • • • • • • • • • Ultracentrifuge (Beckman, Optima TL ultracentrifuge) SpeedVac (Thermo Scientific, cat. no. SPD111V) Savant RVT4104 refrigerated vapor trap with Savant SC110 SpeedVac (Savant) TEM JEOL JEM 1011 transmission electron microscope (JEOL) AMT digital imaging system (Advanced Microscopy Techniques) ELISA ELISA plate reader (Bio-Tek Synergy 2 microplate reader powered by Gen5 analysis software) LDH ELISA plate reader (Bio-Tek Synergy 2 microplate reader powered by Gen5 analysis software) REAGENT SETUP Lentivirus We obtained the lentiviral polycistronic vectors (CSCW-IRES-GFP and CSCW-IRES-mCherry) from the Massachusetts General Hospital (MGH) viral core42, and these are available through the MGH viral core (https://vectorcore.mgh.harvard.edu).

Article Title: A three-dimensional human neural cell culture model of Alzheimer’s disease
Article Snippet: 3D-cultured cell pellets were homogenized in 1 volume of TBS extraction buffer containing 50 mM Tris (pH 7.4), 150 mM NaCl, 1 mM NaVO 3 , 1 mM NaF, a protease inhibitor mixture (Roche Molecular Biochemicals), a phosphatase inhibitor cocktail (Thermo Scientific), 2 mM PNT (EMD Millipore) and 1 mM PMSF (Sigma-Aldrich) by using battery-operated spinning homogenizer (MIDSCI).

Immunofluorescence:

Article Title: A 3D human neural cell culture system for modeling Alzheimer’s disease
Article Snippet: 1121-3810, 1120-1810, 1120-8810 and 1126-7810, respectively) RNase-free micro-centrifuge tubes (1.5 ml size; USA Scientific, cat. no. 1615-5500) PTC-200 Thermal Cycler (MJ Research, cat. no. ALD-1244) iCycler iQ TM (Bio-rad, cat. no. 170-8740) Bio-rad Tetrad® 2 Thermal Cycler (Bio-rad, cat. no. PTC-0240G with ALS-1296GC) NanoDrop 1000 Spectrophotometer (Thermo Scientific, cat. no. ND-1000) Bio-rad ChemiDoc XRS System (Bio-rad, cat. no. 170-8070) Immunofluorescence and Immunohistochemistry list-behavior=unordered prefix-word= mark-type=disc max-label-size=0 Olympus IX7 fluorescence microscope equipped with spinning disk confocal unit (Olympus) LSM Pascal 5 Carl Zeiss confocal microscope (Zeiss) Biochemical Extraction and Western Blot list-behavior=unordered prefix-word= mark-type=disc max-label-size=0 Hoefer Semi-Dry Transfer Unit (Hoefer, TE77) Molecular imager (Bio-rad, VersaDoc MP4000) Battery-operated spinning homogenizer (MIDSCI, cat. no. A0001) Ultracentrifuge tubes (Beckman Coulter, cat. no. 343778) Ultracentrifuge (Beckman, Optima TL Ultracentrifuge) SpeedVac (Thermo Scientific, cat. no. SPD111V) Savant RVT4104 refrigerated vapor trap with Savant SC110 SpeedVac (Savant) TEM list-behavior=unordered prefix-word= mark-type=disc max-label-size=0 JEOL JEM 1011 transmission electron microscope (JEOL) AMT digital imaging system (Advanced Microscopy Techniques) ELISA list-behavior=unordered prefix-word= mark-type=disc max-label-size=0 ELISA plate reader (Bio-Tek Synergy 2 microplate reader) LDH list-behavior=unordered prefix-word= mark-type=disc max-label-size=0 ELISA plate reader (Bio-Tek Synergy 2 microplate reader)

Article Title: A three-dimensional human neural cell culture model of Alzheimer’s disease
Article Snippet: Differential detergent extraction for WB The thick-layer 3D cultures of ReN cells were homogenized with TBS extraction buffer containing 50 mM Tris (pH 7.4), 150 mM NaCl, 1 mM NaVO 3 , 1 mM NaF, a protease inhibitor mixture (Roche Molecular Biochemicals), a phosphatase inhibitor cocktail (Thermo Scientific,), 2 mM PNT (EMD Millipore) and 1 mM Phenylmethylsulfonyl fluoride (PMSF, Sigma-Aldrich) by using battery-operated spinning homogenizer (MIDSCI, St. Louis, MO, USA).

Article Title: A 3D human neural cell culture system for modeling Alzheimer's disease
Article Snippet: 1121-3810, 1120-1810, 1120-8810 and 1126-7810, respectively) RNase-free microcentrifuge tubes (1.5 ml size; USA Scientific, cat. no. 1615-5500) PTC-200 thermal cycler (MJ Research, cat. no. ALD-1244) iCycler iQ (Bio-Rad, cat. no. 170-8740) Bio-Rad Tetrad 2 thermal cycler (Bio-Rad, cat. no. PTC-0240G with ALS-1296GC) NanoDrop 1000 spectrophotometer (Thermo Scientific, cat. no. ND-1000) Bio-Rad ChemiDoc XRS system (Bio-Rad, cat. no. 170-8070) IF and immunohistochemistry Olympus IX7 fluorescence microscope equipped with a spinning disk confocal unit (Olympus) LSM Pascal 5 Carl Zeiss confocal microscope (Zeiss) Biochemical extraction and western blotting Hoefer semi-dry transfer unit (Hoefer, TE77) Molecular imager (Bio-Rad, VersaDoc MP4000) Battery-operated spinning homogenizer (MIDSCI, cat. no. A0001) Ultracentrifuge tubes (Beckman Coulter, cat. no. 343778) • • • • • • • • • • • • • • • • • • • • • • • • Ultracentrifuge (Beckman, Optima TL ultracentrifuge) SpeedVac (Thermo Scientific, cat. no. SPD111V) Savant RVT4104 refrigerated vapor trap with Savant SC110 SpeedVac (Savant) TEM JEOL JEM 1011 transmission electron microscope (JEOL) AMT digital imaging system (Advanced Microscopy Techniques) ELISA ELISA plate reader (Bio-Tek Synergy 2 microplate reader powered by Gen5 analysis software) LDH ELISA plate reader (Bio-Tek Synergy 2 microplate reader powered by Gen5 analysis software) REAGENT SETUP Lentivirus We obtained the lentiviral polycistronic vectors (CSCW-IRES-GFP and CSCW-IRES-mCherry) from the Massachusetts General Hospital (MGH) viral core42, and these are available through the MGH viral core (https://vectorcore.mgh.harvard.edu).

Article Title: A three-dimensional human neural cell culture model of Alzheimer’s disease
Article Snippet: 3D-cultured cell pellets were homogenized in 1 volume of TBS extraction buffer containing 50 mM Tris (pH 7.4), 150 mM NaCl, 1 mM NaVO 3 , 1 mM NaF, a protease inhibitor mixture (Roche Molecular Biochemicals), a phosphatase inhibitor cocktail (Thermo Scientific), 2 mM PNT (EMD Millipore) and 1 mM PMSF (Sigma-Aldrich) by using battery-operated spinning homogenizer (MIDSCI).

Immunohistochemistry:

Article Title: A 3D human neural cell culture system for modeling Alzheimer’s disease
Article Snippet: 1121-3810, 1120-1810, 1120-8810 and 1126-7810, respectively) RNase-free micro-centrifuge tubes (1.5 ml size; USA Scientific, cat. no. 1615-5500) PTC-200 Thermal Cycler (MJ Research, cat. no. ALD-1244) iCycler iQ TM (Bio-rad, cat. no. 170-8740) Bio-rad Tetrad® 2 Thermal Cycler (Bio-rad, cat. no. PTC-0240G with ALS-1296GC) NanoDrop 1000 Spectrophotometer (Thermo Scientific, cat. no. ND-1000) Bio-rad ChemiDoc XRS System (Bio-rad, cat. no. 170-8070) Immunofluorescence and Immunohistochemistry list-behavior=unordered prefix-word= mark-type=disc max-label-size=0 Olympus IX7 fluorescence microscope equipped with spinning disk confocal unit (Olympus) LSM Pascal 5 Carl Zeiss confocal microscope (Zeiss) Biochemical Extraction and Western Blot list-behavior=unordered prefix-word= mark-type=disc max-label-size=0 Hoefer Semi-Dry Transfer Unit (Hoefer, TE77) Molecular imager (Bio-rad, VersaDoc MP4000) Battery-operated spinning homogenizer (MIDSCI, cat. no. A0001) Ultracentrifuge tubes (Beckman Coulter, cat. no. 343778) Ultracentrifuge (Beckman, Optima TL Ultracentrifuge) SpeedVac (Thermo Scientific, cat. no. SPD111V) Savant RVT4104 refrigerated vapor trap with Savant SC110 SpeedVac (Savant) TEM list-behavior=unordered prefix-word= mark-type=disc max-label-size=0 JEOL JEM 1011 transmission electron microscope (JEOL) AMT digital imaging system (Advanced Microscopy Techniques) ELISA list-behavior=unordered prefix-word= mark-type=disc max-label-size=0 ELISA plate reader (Bio-Tek Synergy 2 microplate reader) LDH list-behavior=unordered prefix-word= mark-type=disc max-label-size=0 ELISA plate reader (Bio-Tek Synergy 2 microplate reader)

Article Title: A three-dimensional human neural cell culture model of Alzheimer’s disease
Article Snippet: Differential detergent extraction for WB The thick-layer 3D cultures of ReN cells were homogenized with TBS extraction buffer containing 50 mM Tris (pH 7.4), 150 mM NaCl, 1 mM NaVO 3 , 1 mM NaF, a protease inhibitor mixture (Roche Molecular Biochemicals), a phosphatase inhibitor cocktail (Thermo Scientific,), 2 mM PNT (EMD Millipore) and 1 mM Phenylmethylsulfonyl fluoride (PMSF, Sigma-Aldrich) by using battery-operated spinning homogenizer (MIDSCI, St. Louis, MO, USA).

Article Title: A 3D human neural cell culture system for modeling Alzheimer's disease
Article Snippet: 1121-3810, 1120-1810, 1120-8810 and 1126-7810, respectively) RNase-free microcentrifuge tubes (1.5 ml size; USA Scientific, cat. no. 1615-5500) PTC-200 thermal cycler (MJ Research, cat. no. ALD-1244) iCycler iQ (Bio-Rad, cat. no. 170-8740) Bio-Rad Tetrad 2 thermal cycler (Bio-Rad, cat. no. PTC-0240G with ALS-1296GC) NanoDrop 1000 spectrophotometer (Thermo Scientific, cat. no. ND-1000) Bio-Rad ChemiDoc XRS system (Bio-Rad, cat. no. 170-8070) IF and immunohistochemistry Olympus IX7 fluorescence microscope equipped with a spinning disk confocal unit (Olympus) LSM Pascal 5 Carl Zeiss confocal microscope (Zeiss) Biochemical extraction and western blotting Hoefer semi-dry transfer unit (Hoefer, TE77) Molecular imager (Bio-Rad, VersaDoc MP4000) Battery-operated spinning homogenizer (MIDSCI, cat. no. A0001) Ultracentrifuge tubes (Beckman Coulter, cat. no. 343778) • • • • • • • • • • • • • • • • • • • • • • • • Ultracentrifuge (Beckman, Optima TL ultracentrifuge) SpeedVac (Thermo Scientific, cat. no. SPD111V) Savant RVT4104 refrigerated vapor trap with Savant SC110 SpeedVac (Savant) TEM JEOL JEM 1011 transmission electron microscope (JEOL) AMT digital imaging system (Advanced Microscopy Techniques) ELISA ELISA plate reader (Bio-Tek Synergy 2 microplate reader powered by Gen5 analysis software) LDH ELISA plate reader (Bio-Tek Synergy 2 microplate reader powered by Gen5 analysis software) REAGENT SETUP Lentivirus We obtained the lentiviral polycistronic vectors (CSCW-IRES-GFP and CSCW-IRES-mCherry) from the Massachusetts General Hospital (MGH) viral core42, and these are available through the MGH viral core (https://vectorcore.mgh.harvard.edu).

Article Title: A three-dimensional human neural cell culture model of Alzheimer’s disease
Article Snippet: 3D-cultured cell pellets were homogenized in 1 volume of TBS extraction buffer containing 50 mM Tris (pH 7.4), 150 mM NaCl, 1 mM NaVO 3 , 1 mM NaF, a protease inhibitor mixture (Roche Molecular Biochemicals), a phosphatase inhibitor cocktail (Thermo Scientific), 2 mM PNT (EMD Millipore) and 1 mM PMSF (Sigma-Aldrich) by using battery-operated spinning homogenizer (MIDSCI).

Fluorescence:

Article Title: A 3D human neural cell culture system for modeling Alzheimer’s disease
Article Snippet: 1121-3810, 1120-1810, 1120-8810 and 1126-7810, respectively) RNase-free micro-centrifuge tubes (1.5 ml size; USA Scientific, cat. no. 1615-5500) PTC-200 Thermal Cycler (MJ Research, cat. no. ALD-1244) iCycler iQ TM (Bio-rad, cat. no. 170-8740) Bio-rad Tetrad® 2 Thermal Cycler (Bio-rad, cat. no. PTC-0240G with ALS-1296GC) NanoDrop 1000 Spectrophotometer (Thermo Scientific, cat. no. ND-1000) Bio-rad ChemiDoc XRS System (Bio-rad, cat. no. 170-8070) Immunofluorescence and Immunohistochemistry list-behavior=unordered prefix-word= mark-type=disc max-label-size=0 Olympus IX7 fluorescence microscope equipped with spinning disk confocal unit (Olympus) LSM Pascal 5 Carl Zeiss confocal microscope (Zeiss) Biochemical Extraction and Western Blot list-behavior=unordered prefix-word= mark-type=disc max-label-size=0 Hoefer Semi-Dry Transfer Unit (Hoefer, TE77) Molecular imager (Bio-rad, VersaDoc MP4000) Battery-operated spinning homogenizer (MIDSCI, cat. no. A0001) Ultracentrifuge tubes (Beckman Coulter, cat. no. 343778) Ultracentrifuge (Beckman, Optima TL Ultracentrifuge) SpeedVac (Thermo Scientific, cat. no. SPD111V) Savant RVT4104 refrigerated vapor trap with Savant SC110 SpeedVac (Savant) TEM list-behavior=unordered prefix-word= mark-type=disc max-label-size=0 JEOL JEM 1011 transmission electron microscope (JEOL) AMT digital imaging system (Advanced Microscopy Techniques) ELISA list-behavior=unordered prefix-word= mark-type=disc max-label-size=0 ELISA plate reader (Bio-Tek Synergy 2 microplate reader) LDH list-behavior=unordered prefix-word= mark-type=disc max-label-size=0 ELISA plate reader (Bio-Tek Synergy 2 microplate reader)

Article Title: A three-dimensional human neural cell culture model of Alzheimer’s disease
Article Snippet: Differential detergent extraction for WB The thick-layer 3D cultures of ReN cells were homogenized with TBS extraction buffer containing 50 mM Tris (pH 7.4), 150 mM NaCl, 1 mM NaVO 3 , 1 mM NaF, a protease inhibitor mixture (Roche Molecular Biochemicals), a phosphatase inhibitor cocktail (Thermo Scientific,), 2 mM PNT (EMD Millipore) and 1 mM Phenylmethylsulfonyl fluoride (PMSF, Sigma-Aldrich) by using battery-operated spinning homogenizer (MIDSCI, St. Louis, MO, USA).

Article Title: A 3D human neural cell culture system for modeling Alzheimer's disease
Article Snippet: 1121-3810, 1120-1810, 1120-8810 and 1126-7810, respectively) RNase-free microcentrifuge tubes (1.5 ml size; USA Scientific, cat. no. 1615-5500) PTC-200 thermal cycler (MJ Research, cat. no. ALD-1244) iCycler iQ (Bio-Rad, cat. no. 170-8740) Bio-Rad Tetrad 2 thermal cycler (Bio-Rad, cat. no. PTC-0240G with ALS-1296GC) NanoDrop 1000 spectrophotometer (Thermo Scientific, cat. no. ND-1000) Bio-Rad ChemiDoc XRS system (Bio-Rad, cat. no. 170-8070) IF and immunohistochemistry Olympus IX7 fluorescence microscope equipped with a spinning disk confocal unit (Olympus) LSM Pascal 5 Carl Zeiss confocal microscope (Zeiss) Biochemical extraction and western blotting Hoefer semi-dry transfer unit (Hoefer, TE77) Molecular imager (Bio-Rad, VersaDoc MP4000) Battery-operated spinning homogenizer (MIDSCI, cat. no. A0001) Ultracentrifuge tubes (Beckman Coulter, cat. no. 343778) • • • • • • • • • • • • • • • • • • • • • • • • Ultracentrifuge (Beckman, Optima TL ultracentrifuge) SpeedVac (Thermo Scientific, cat. no. SPD111V) Savant RVT4104 refrigerated vapor trap with Savant SC110 SpeedVac (Savant) TEM JEOL JEM 1011 transmission electron microscope (JEOL) AMT digital imaging system (Advanced Microscopy Techniques) ELISA ELISA plate reader (Bio-Tek Synergy 2 microplate reader powered by Gen5 analysis software) LDH ELISA plate reader (Bio-Tek Synergy 2 microplate reader powered by Gen5 analysis software) REAGENT SETUP Lentivirus We obtained the lentiviral polycistronic vectors (CSCW-IRES-GFP and CSCW-IRES-mCherry) from the Massachusetts General Hospital (MGH) viral core42, and these are available through the MGH viral core (https://vectorcore.mgh.harvard.edu).

Article Title: A three-dimensional human neural cell culture model of Alzheimer’s disease
Article Snippet: 3D-cultured cell pellets were homogenized in 1 volume of TBS extraction buffer containing 50 mM Tris (pH 7.4), 150 mM NaCl, 1 mM NaVO 3 , 1 mM NaF, a protease inhibitor mixture (Roche Molecular Biochemicals), a phosphatase inhibitor cocktail (Thermo Scientific), 2 mM PNT (EMD Millipore) and 1 mM PMSF (Sigma-Aldrich) by using battery-operated spinning homogenizer (MIDSCI).

Microscopy:

Article Title: A 3D human neural cell culture system for modeling Alzheimer’s disease
Article Snippet: 1121-3810, 1120-1810, 1120-8810 and 1126-7810, respectively) RNase-free micro-centrifuge tubes (1.5 ml size; USA Scientific, cat. no. 1615-5500) PTC-200 Thermal Cycler (MJ Research, cat. no. ALD-1244) iCycler iQ TM (Bio-rad, cat. no. 170-8740) Bio-rad Tetrad® 2 Thermal Cycler (Bio-rad, cat. no. PTC-0240G with ALS-1296GC) NanoDrop 1000 Spectrophotometer (Thermo Scientific, cat. no. ND-1000) Bio-rad ChemiDoc XRS System (Bio-rad, cat. no. 170-8070) Immunofluorescence and Immunohistochemistry list-behavior=unordered prefix-word= mark-type=disc max-label-size=0 Olympus IX7 fluorescence microscope equipped with spinning disk confocal unit (Olympus) LSM Pascal 5 Carl Zeiss confocal microscope (Zeiss) Biochemical Extraction and Western Blot list-behavior=unordered prefix-word= mark-type=disc max-label-size=0 Hoefer Semi-Dry Transfer Unit (Hoefer, TE77) Molecular imager (Bio-rad, VersaDoc MP4000) Battery-operated spinning homogenizer (MIDSCI, cat. no. A0001) Ultracentrifuge tubes (Beckman Coulter, cat. no. 343778) Ultracentrifuge (Beckman, Optima TL Ultracentrifuge) SpeedVac (Thermo Scientific, cat. no. SPD111V) Savant RVT4104 refrigerated vapor trap with Savant SC110 SpeedVac (Savant) TEM list-behavior=unordered prefix-word= mark-type=disc max-label-size=0 JEOL JEM 1011 transmission electron microscope (JEOL) AMT digital imaging system (Advanced Microscopy Techniques) ELISA list-behavior=unordered prefix-word= mark-type=disc max-label-size=0 ELISA plate reader (Bio-Tek Synergy 2 microplate reader) LDH list-behavior=unordered prefix-word= mark-type=disc max-label-size=0 ELISA plate reader (Bio-Tek Synergy 2 microplate reader)

Article Title: A three-dimensional human neural cell culture model of Alzheimer’s disease
Article Snippet: Differential detergent extraction for WB The thick-layer 3D cultures of ReN cells were homogenized with TBS extraction buffer containing 50 mM Tris (pH 7.4), 150 mM NaCl, 1 mM NaVO 3 , 1 mM NaF, a protease inhibitor mixture (Roche Molecular Biochemicals), a phosphatase inhibitor cocktail (Thermo Scientific,), 2 mM PNT (EMD Millipore) and 1 mM Phenylmethylsulfonyl fluoride (PMSF, Sigma-Aldrich) by using battery-operated spinning homogenizer (MIDSCI, St. Louis, MO, USA).

Article Title: A 3D human neural cell culture system for modeling Alzheimer's disease
Article Snippet: 1121-3810, 1120-1810, 1120-8810 and 1126-7810, respectively) RNase-free microcentrifuge tubes (1.5 ml size; USA Scientific, cat. no. 1615-5500) PTC-200 thermal cycler (MJ Research, cat. no. ALD-1244) iCycler iQ (Bio-Rad, cat. no. 170-8740) Bio-Rad Tetrad 2 thermal cycler (Bio-Rad, cat. no. PTC-0240G with ALS-1296GC) NanoDrop 1000 spectrophotometer (Thermo Scientific, cat. no. ND-1000) Bio-Rad ChemiDoc XRS system (Bio-Rad, cat. no. 170-8070) IF and immunohistochemistry Olympus IX7 fluorescence microscope equipped with a spinning disk confocal unit (Olympus) LSM Pascal 5 Carl Zeiss confocal microscope (Zeiss) Biochemical extraction and western blotting Hoefer semi-dry transfer unit (Hoefer, TE77) Molecular imager (Bio-Rad, VersaDoc MP4000) Battery-operated spinning homogenizer (MIDSCI, cat. no. A0001) Ultracentrifuge tubes (Beckman Coulter, cat. no. 343778) • • • • • • • • • • • • • • • • • • • • • • • • Ultracentrifuge (Beckman, Optima TL ultracentrifuge) SpeedVac (Thermo Scientific, cat. no. SPD111V) Savant RVT4104 refrigerated vapor trap with Savant SC110 SpeedVac (Savant) TEM JEOL JEM 1011 transmission electron microscope (JEOL) AMT digital imaging system (Advanced Microscopy Techniques) ELISA ELISA plate reader (Bio-Tek Synergy 2 microplate reader powered by Gen5 analysis software) LDH ELISA plate reader (Bio-Tek Synergy 2 microplate reader powered by Gen5 analysis software) REAGENT SETUP Lentivirus We obtained the lentiviral polycistronic vectors (CSCW-IRES-GFP and CSCW-IRES-mCherry) from the Massachusetts General Hospital (MGH) viral core42, and these are available through the MGH viral core (https://vectorcore.mgh.harvard.edu).

Article Title: A three-dimensional human neural cell culture model of Alzheimer’s disease
Article Snippet: 3D-cultured cell pellets were homogenized in 1 volume of TBS extraction buffer containing 50 mM Tris (pH 7.4), 150 mM NaCl, 1 mM NaVO 3 , 1 mM NaF, a protease inhibitor mixture (Roche Molecular Biochemicals), a phosphatase inhibitor cocktail (Thermo Scientific), 2 mM PNT (EMD Millipore) and 1 mM PMSF (Sigma-Aldrich) by using battery-operated spinning homogenizer (MIDSCI).

Western Blot:

Article Title: A 3D human neural cell culture system for modeling Alzheimer’s disease
Article Snippet: 1121-3810, 1120-1810, 1120-8810 and 1126-7810, respectively) RNase-free micro-centrifuge tubes (1.5 ml size; USA Scientific, cat. no. 1615-5500) PTC-200 Thermal Cycler (MJ Research, cat. no. ALD-1244) iCycler iQ TM (Bio-rad, cat. no. 170-8740) Bio-rad Tetrad® 2 Thermal Cycler (Bio-rad, cat. no. PTC-0240G with ALS-1296GC) NanoDrop 1000 Spectrophotometer (Thermo Scientific, cat. no. ND-1000) Bio-rad ChemiDoc XRS System (Bio-rad, cat. no. 170-8070) Immunofluorescence and Immunohistochemistry list-behavior=unordered prefix-word= mark-type=disc max-label-size=0 Olympus IX7 fluorescence microscope equipped with spinning disk confocal unit (Olympus) LSM Pascal 5 Carl Zeiss confocal microscope (Zeiss) Biochemical Extraction and Western Blot list-behavior=unordered prefix-word= mark-type=disc max-label-size=0 Hoefer Semi-Dry Transfer Unit (Hoefer, TE77) Molecular imager (Bio-rad, VersaDoc MP4000) Battery-operated spinning homogenizer (MIDSCI, cat. no. A0001) Ultracentrifuge tubes (Beckman Coulter, cat. no. 343778) Ultracentrifuge (Beckman, Optima TL Ultracentrifuge) SpeedVac (Thermo Scientific, cat. no. SPD111V) Savant RVT4104 refrigerated vapor trap with Savant SC110 SpeedVac (Savant) TEM list-behavior=unordered prefix-word= mark-type=disc max-label-size=0 JEOL JEM 1011 transmission electron microscope (JEOL) AMT digital imaging system (Advanced Microscopy Techniques) ELISA list-behavior=unordered prefix-word= mark-type=disc max-label-size=0 ELISA plate reader (Bio-Tek Synergy 2 microplate reader) LDH list-behavior=unordered prefix-word= mark-type=disc max-label-size=0 ELISA plate reader (Bio-Tek Synergy 2 microplate reader)

Article Title: A three-dimensional human neural cell culture model of Alzheimer’s disease
Article Snippet: Differential detergent extraction for WB The thick-layer 3D cultures of ReN cells were homogenized with TBS extraction buffer containing 50 mM Tris (pH 7.4), 150 mM NaCl, 1 mM NaVO 3 , 1 mM NaF, a protease inhibitor mixture (Roche Molecular Biochemicals), a phosphatase inhibitor cocktail (Thermo Scientific,), 2 mM PNT (EMD Millipore) and 1 mM Phenylmethylsulfonyl fluoride (PMSF, Sigma-Aldrich) by using battery-operated spinning homogenizer (MIDSCI, St. Louis, MO, USA).

Article Title: A 3D human neural cell culture system for modeling Alzheimer's disease
Article Snippet: 1121-3810, 1120-1810, 1120-8810 and 1126-7810, respectively) RNase-free microcentrifuge tubes (1.5 ml size; USA Scientific, cat. no. 1615-5500) PTC-200 thermal cycler (MJ Research, cat. no. ALD-1244) iCycler iQ (Bio-Rad, cat. no. 170-8740) Bio-Rad Tetrad 2 thermal cycler (Bio-Rad, cat. no. PTC-0240G with ALS-1296GC) NanoDrop 1000 spectrophotometer (Thermo Scientific, cat. no. ND-1000) Bio-Rad ChemiDoc XRS system (Bio-Rad, cat. no. 170-8070) IF and immunohistochemistry Olympus IX7 fluorescence microscope equipped with a spinning disk confocal unit (Olympus) LSM Pascal 5 Carl Zeiss confocal microscope (Zeiss) Biochemical extraction and western blotting Hoefer semi-dry transfer unit (Hoefer, TE77) Molecular imager (Bio-Rad, VersaDoc MP4000) Battery-operated spinning homogenizer (MIDSCI, cat. no. A0001) Ultracentrifuge tubes (Beckman Coulter, cat. no. 343778) • • • • • • • • • • • • • • • • • • • • • • • • Ultracentrifuge (Beckman, Optima TL ultracentrifuge) SpeedVac (Thermo Scientific, cat. no. SPD111V) Savant RVT4104 refrigerated vapor trap with Savant SC110 SpeedVac (Savant) TEM JEOL JEM 1011 transmission electron microscope (JEOL) AMT digital imaging system (Advanced Microscopy Techniques) ELISA ELISA plate reader (Bio-Tek Synergy 2 microplate reader powered by Gen5 analysis software) LDH ELISA plate reader (Bio-Tek Synergy 2 microplate reader powered by Gen5 analysis software) REAGENT SETUP Lentivirus We obtained the lentiviral polycistronic vectors (CSCW-IRES-GFP and CSCW-IRES-mCherry) from the Massachusetts General Hospital (MGH) viral core42, and these are available through the MGH viral core (https://vectorcore.mgh.harvard.edu).

Article Title: A three-dimensional human neural cell culture model of Alzheimer’s disease
Article Snippet: 3D-cultured cell pellets were homogenized in 1 volume of TBS extraction buffer containing 50 mM Tris (pH 7.4), 150 mM NaCl, 1 mM NaVO 3 , 1 mM NaF, a protease inhibitor mixture (Roche Molecular Biochemicals), a phosphatase inhibitor cocktail (Thermo Scientific), 2 mM PNT (EMD Millipore) and 1 mM PMSF (Sigma-Aldrich) by using battery-operated spinning homogenizer (MIDSCI).

Transmission Electron Microscopy:

Article Title: A 3D human neural cell culture system for modeling Alzheimer’s disease
Article Snippet: 1121-3810, 1120-1810, 1120-8810 and 1126-7810, respectively) RNase-free micro-centrifuge tubes (1.5 ml size; USA Scientific, cat. no. 1615-5500) PTC-200 Thermal Cycler (MJ Research, cat. no. ALD-1244) iCycler iQ TM (Bio-rad, cat. no. 170-8740) Bio-rad Tetrad® 2 Thermal Cycler (Bio-rad, cat. no. PTC-0240G with ALS-1296GC) NanoDrop 1000 Spectrophotometer (Thermo Scientific, cat. no. ND-1000) Bio-rad ChemiDoc XRS System (Bio-rad, cat. no. 170-8070) Immunofluorescence and Immunohistochemistry list-behavior=unordered prefix-word= mark-type=disc max-label-size=0 Olympus IX7 fluorescence microscope equipped with spinning disk confocal unit (Olympus) LSM Pascal 5 Carl Zeiss confocal microscope (Zeiss) Biochemical Extraction and Western Blot list-behavior=unordered prefix-word= mark-type=disc max-label-size=0 Hoefer Semi-Dry Transfer Unit (Hoefer, TE77) Molecular imager (Bio-rad, VersaDoc MP4000) Battery-operated spinning homogenizer (MIDSCI, cat. no. A0001) Ultracentrifuge tubes (Beckman Coulter, cat. no. 343778) Ultracentrifuge (Beckman, Optima TL Ultracentrifuge) SpeedVac (Thermo Scientific, cat. no. SPD111V) Savant RVT4104 refrigerated vapor trap with Savant SC110 SpeedVac (Savant) TEM list-behavior=unordered prefix-word= mark-type=disc max-label-size=0 JEOL JEM 1011 transmission electron microscope (JEOL) AMT digital imaging system (Advanced Microscopy Techniques) ELISA list-behavior=unordered prefix-word= mark-type=disc max-label-size=0 ELISA plate reader (Bio-Tek Synergy 2 microplate reader) LDH list-behavior=unordered prefix-word= mark-type=disc max-label-size=0 ELISA plate reader (Bio-Tek Synergy 2 microplate reader)

Article Title: A three-dimensional human neural cell culture model of Alzheimer’s disease
Article Snippet: Differential detergent extraction for WB The thick-layer 3D cultures of ReN cells were homogenized with TBS extraction buffer containing 50 mM Tris (pH 7.4), 150 mM NaCl, 1 mM NaVO 3 , 1 mM NaF, a protease inhibitor mixture (Roche Molecular Biochemicals), a phosphatase inhibitor cocktail (Thermo Scientific,), 2 mM PNT (EMD Millipore) and 1 mM Phenylmethylsulfonyl fluoride (PMSF, Sigma-Aldrich) by using battery-operated spinning homogenizer (MIDSCI, St. Louis, MO, USA).

Article Title: A 3D human neural cell culture system for modeling Alzheimer's disease
Article Snippet: 1121-3810, 1120-1810, 1120-8810 and 1126-7810, respectively) RNase-free microcentrifuge tubes (1.5 ml size; USA Scientific, cat. no. 1615-5500) PTC-200 thermal cycler (MJ Research, cat. no. ALD-1244) iCycler iQ (Bio-Rad, cat. no. 170-8740) Bio-Rad Tetrad 2 thermal cycler (Bio-Rad, cat. no. PTC-0240G with ALS-1296GC) NanoDrop 1000 spectrophotometer (Thermo Scientific, cat. no. ND-1000) Bio-Rad ChemiDoc XRS system (Bio-Rad, cat. no. 170-8070) IF and immunohistochemistry Olympus IX7 fluorescence microscope equipped with a spinning disk confocal unit (Olympus) LSM Pascal 5 Carl Zeiss confocal microscope (Zeiss) Biochemical extraction and western blotting Hoefer semi-dry transfer unit (Hoefer, TE77) Molecular imager (Bio-Rad, VersaDoc MP4000) Battery-operated spinning homogenizer (MIDSCI, cat. no. A0001) Ultracentrifuge tubes (Beckman Coulter, cat. no. 343778) • • • • • • • • • • • • • • • • • • • • • • • • Ultracentrifuge (Beckman, Optima TL ultracentrifuge) SpeedVac (Thermo Scientific, cat. no. SPD111V) Savant RVT4104 refrigerated vapor trap with Savant SC110 SpeedVac (Savant) TEM JEOL JEM 1011 transmission electron microscope (JEOL) AMT digital imaging system (Advanced Microscopy Techniques) ELISA ELISA plate reader (Bio-Tek Synergy 2 microplate reader powered by Gen5 analysis software) LDH ELISA plate reader (Bio-Tek Synergy 2 microplate reader powered by Gen5 analysis software) REAGENT SETUP Lentivirus We obtained the lentiviral polycistronic vectors (CSCW-IRES-GFP and CSCW-IRES-mCherry) from the Massachusetts General Hospital (MGH) viral core42, and these are available through the MGH viral core (https://vectorcore.mgh.harvard.edu).

Article Title: A three-dimensional human neural cell culture model of Alzheimer’s disease
Article Snippet: 3D-cultured cell pellets were homogenized in 1 volume of TBS extraction buffer containing 50 mM Tris (pH 7.4), 150 mM NaCl, 1 mM NaVO 3 , 1 mM NaF, a protease inhibitor mixture (Roche Molecular Biochemicals), a phosphatase inhibitor cocktail (Thermo Scientific), 2 mM PNT (EMD Millipore) and 1 mM PMSF (Sigma-Aldrich) by using battery-operated spinning homogenizer (MIDSCI).

Transmission Assay:

Article Title: A 3D human neural cell culture system for modeling Alzheimer’s disease
Article Snippet: 1121-3810, 1120-1810, 1120-8810 and 1126-7810, respectively) RNase-free micro-centrifuge tubes (1.5 ml size; USA Scientific, cat. no. 1615-5500) PTC-200 Thermal Cycler (MJ Research, cat. no. ALD-1244) iCycler iQ TM (Bio-rad, cat. no. 170-8740) Bio-rad Tetrad® 2 Thermal Cycler (Bio-rad, cat. no. PTC-0240G with ALS-1296GC) NanoDrop 1000 Spectrophotometer (Thermo Scientific, cat. no. ND-1000) Bio-rad ChemiDoc XRS System (Bio-rad, cat. no. 170-8070) Immunofluorescence and Immunohistochemistry list-behavior=unordered prefix-word= mark-type=disc max-label-size=0 Olympus IX7 fluorescence microscope equipped with spinning disk confocal unit (Olympus) LSM Pascal 5 Carl Zeiss confocal microscope (Zeiss) Biochemical Extraction and Western Blot list-behavior=unordered prefix-word= mark-type=disc max-label-size=0 Hoefer Semi-Dry Transfer Unit (Hoefer, TE77) Molecular imager (Bio-rad, VersaDoc MP4000) Battery-operated spinning homogenizer (MIDSCI, cat. no. A0001) Ultracentrifuge tubes (Beckman Coulter, cat. no. 343778) Ultracentrifuge (Beckman, Optima TL Ultracentrifuge) SpeedVac (Thermo Scientific, cat. no. SPD111V) Savant RVT4104 refrigerated vapor trap with Savant SC110 SpeedVac (Savant) TEM list-behavior=unordered prefix-word= mark-type=disc max-label-size=0 JEOL JEM 1011 transmission electron microscope (JEOL) AMT digital imaging system (Advanced Microscopy Techniques) ELISA list-behavior=unordered prefix-word= mark-type=disc max-label-size=0 ELISA plate reader (Bio-Tek Synergy 2 microplate reader) LDH list-behavior=unordered prefix-word= mark-type=disc max-label-size=0 ELISA plate reader (Bio-Tek Synergy 2 microplate reader)

Article Title: A three-dimensional human neural cell culture model of Alzheimer’s disease
Article Snippet: Differential detergent extraction for WB The thick-layer 3D cultures of ReN cells were homogenized with TBS extraction buffer containing 50 mM Tris (pH 7.4), 150 mM NaCl, 1 mM NaVO 3 , 1 mM NaF, a protease inhibitor mixture (Roche Molecular Biochemicals), a phosphatase inhibitor cocktail (Thermo Scientific,), 2 mM PNT (EMD Millipore) and 1 mM Phenylmethylsulfonyl fluoride (PMSF, Sigma-Aldrich) by using battery-operated spinning homogenizer (MIDSCI, St. Louis, MO, USA).

Article Title: A 3D human neural cell culture system for modeling Alzheimer's disease
Article Snippet: 1121-3810, 1120-1810, 1120-8810 and 1126-7810, respectively) RNase-free microcentrifuge tubes (1.5 ml size; USA Scientific, cat. no. 1615-5500) PTC-200 thermal cycler (MJ Research, cat. no. ALD-1244) iCycler iQ (Bio-Rad, cat. no. 170-8740) Bio-Rad Tetrad 2 thermal cycler (Bio-Rad, cat. no. PTC-0240G with ALS-1296GC) NanoDrop 1000 spectrophotometer (Thermo Scientific, cat. no. ND-1000) Bio-Rad ChemiDoc XRS system (Bio-Rad, cat. no. 170-8070) IF and immunohistochemistry Olympus IX7 fluorescence microscope equipped with a spinning disk confocal unit (Olympus) LSM Pascal 5 Carl Zeiss confocal microscope (Zeiss) Biochemical extraction and western blotting Hoefer semi-dry transfer unit (Hoefer, TE77) Molecular imager (Bio-Rad, VersaDoc MP4000) Battery-operated spinning homogenizer (MIDSCI, cat. no. A0001) Ultracentrifuge tubes (Beckman Coulter, cat. no. 343778) • • • • • • • • • • • • • • • • • • • • • • • • Ultracentrifuge (Beckman, Optima TL ultracentrifuge) SpeedVac (Thermo Scientific, cat. no. SPD111V) Savant RVT4104 refrigerated vapor trap with Savant SC110 SpeedVac (Savant) TEM JEOL JEM 1011 transmission electron microscope (JEOL) AMT digital imaging system (Advanced Microscopy Techniques) ELISA ELISA plate reader (Bio-Tek Synergy 2 microplate reader powered by Gen5 analysis software) LDH ELISA plate reader (Bio-Tek Synergy 2 microplate reader powered by Gen5 analysis software) REAGENT SETUP Lentivirus We obtained the lentiviral polycistronic vectors (CSCW-IRES-GFP and CSCW-IRES-mCherry) from the Massachusetts General Hospital (MGH) viral core42, and these are available through the MGH viral core (https://vectorcore.mgh.harvard.edu).

Article Title: A three-dimensional human neural cell culture model of Alzheimer’s disease
Article Snippet: 3D-cultured cell pellets were homogenized in 1 volume of TBS extraction buffer containing 50 mM Tris (pH 7.4), 150 mM NaCl, 1 mM NaVO 3 , 1 mM NaF, a protease inhibitor mixture (Roche Molecular Biochemicals), a phosphatase inhibitor cocktail (Thermo Scientific), 2 mM PNT (EMD Millipore) and 1 mM PMSF (Sigma-Aldrich) by using battery-operated spinning homogenizer (MIDSCI).

Imaging:

Article Title: A 3D human neural cell culture system for modeling Alzheimer’s disease
Article Snippet: 1121-3810, 1120-1810, 1120-8810 and 1126-7810, respectively) RNase-free micro-centrifuge tubes (1.5 ml size; USA Scientific, cat. no. 1615-5500) PTC-200 Thermal Cycler (MJ Research, cat. no. ALD-1244) iCycler iQ TM (Bio-rad, cat. no. 170-8740) Bio-rad Tetrad® 2 Thermal Cycler (Bio-rad, cat. no. PTC-0240G with ALS-1296GC) NanoDrop 1000 Spectrophotometer (Thermo Scientific, cat. no. ND-1000) Bio-rad ChemiDoc XRS System (Bio-rad, cat. no. 170-8070) Immunofluorescence and Immunohistochemistry list-behavior=unordered prefix-word= mark-type=disc max-label-size=0 Olympus IX7 fluorescence microscope equipped with spinning disk confocal unit (Olympus) LSM Pascal 5 Carl Zeiss confocal microscope (Zeiss) Biochemical Extraction and Western Blot list-behavior=unordered prefix-word= mark-type=disc max-label-size=0 Hoefer Semi-Dry Transfer Unit (Hoefer, TE77) Molecular imager (Bio-rad, VersaDoc MP4000) Battery-operated spinning homogenizer (MIDSCI, cat. no. A0001) Ultracentrifuge tubes (Beckman Coulter, cat. no. 343778) Ultracentrifuge (Beckman, Optima TL Ultracentrifuge) SpeedVac (Thermo Scientific, cat. no. SPD111V) Savant RVT4104 refrigerated vapor trap with Savant SC110 SpeedVac (Savant) TEM list-behavior=unordered prefix-word= mark-type=disc max-label-size=0 JEOL JEM 1011 transmission electron microscope (JEOL) AMT digital imaging system (Advanced Microscopy Techniques) ELISA list-behavior=unordered prefix-word= mark-type=disc max-label-size=0 ELISA plate reader (Bio-Tek Synergy 2 microplate reader) LDH list-behavior=unordered prefix-word= mark-type=disc max-label-size=0 ELISA plate reader (Bio-Tek Synergy 2 microplate reader)

Article Title: A three-dimensional human neural cell culture model of Alzheimer’s disease
Article Snippet: Differential detergent extraction for WB The thick-layer 3D cultures of ReN cells were homogenized with TBS extraction buffer containing 50 mM Tris (pH 7.4), 150 mM NaCl, 1 mM NaVO 3 , 1 mM NaF, a protease inhibitor mixture (Roche Molecular Biochemicals), a phosphatase inhibitor cocktail (Thermo Scientific,), 2 mM PNT (EMD Millipore) and 1 mM Phenylmethylsulfonyl fluoride (PMSF, Sigma-Aldrich) by using battery-operated spinning homogenizer (MIDSCI, St. Louis, MO, USA).

Article Title: A 3D human neural cell culture system for modeling Alzheimer's disease
Article Snippet: 1121-3810, 1120-1810, 1120-8810 and 1126-7810, respectively) RNase-free microcentrifuge tubes (1.5 ml size; USA Scientific, cat. no. 1615-5500) PTC-200 thermal cycler (MJ Research, cat. no. ALD-1244) iCycler iQ (Bio-Rad, cat. no. 170-8740) Bio-Rad Tetrad 2 thermal cycler (Bio-Rad, cat. no. PTC-0240G with ALS-1296GC) NanoDrop 1000 spectrophotometer (Thermo Scientific, cat. no. ND-1000) Bio-Rad ChemiDoc XRS system (Bio-Rad, cat. no. 170-8070) IF and immunohistochemistry Olympus IX7 fluorescence microscope equipped with a spinning disk confocal unit (Olympus) LSM Pascal 5 Carl Zeiss confocal microscope (Zeiss) Biochemical extraction and western blotting Hoefer semi-dry transfer unit (Hoefer, TE77) Molecular imager (Bio-Rad, VersaDoc MP4000) Battery-operated spinning homogenizer (MIDSCI, cat. no. A0001) Ultracentrifuge tubes (Beckman Coulter, cat. no. 343778) • • • • • • • • • • • • • • • • • • • • • • • • Ultracentrifuge (Beckman, Optima TL ultracentrifuge) SpeedVac (Thermo Scientific, cat. no. SPD111V) Savant RVT4104 refrigerated vapor trap with Savant SC110 SpeedVac (Savant) TEM JEOL JEM 1011 transmission electron microscope (JEOL) AMT digital imaging system (Advanced Microscopy Techniques) ELISA ELISA plate reader (Bio-Tek Synergy 2 microplate reader powered by Gen5 analysis software) LDH ELISA plate reader (Bio-Tek Synergy 2 microplate reader powered by Gen5 analysis software) REAGENT SETUP Lentivirus We obtained the lentiviral polycistronic vectors (CSCW-IRES-GFP and CSCW-IRES-mCherry) from the Massachusetts General Hospital (MGH) viral core42, and these are available through the MGH viral core (https://vectorcore.mgh.harvard.edu).

Article Title: A three-dimensional human neural cell culture model of Alzheimer’s disease
Article Snippet: 3D-cultured cell pellets were homogenized in 1 volume of TBS extraction buffer containing 50 mM Tris (pH 7.4), 150 mM NaCl, 1 mM NaVO 3 , 1 mM NaF, a protease inhibitor mixture (Roche Molecular Biochemicals), a phosphatase inhibitor cocktail (Thermo Scientific), 2 mM PNT (EMD Millipore) and 1 mM PMSF (Sigma-Aldrich) by using battery-operated spinning homogenizer (MIDSCI).

Enzyme-linked Immunosorbent Assay:

Article Title: A 3D human neural cell culture system for modeling Alzheimer’s disease
Article Snippet: 1121-3810, 1120-1810, 1120-8810 and 1126-7810, respectively) RNase-free micro-centrifuge tubes (1.5 ml size; USA Scientific, cat. no. 1615-5500) PTC-200 Thermal Cycler (MJ Research, cat. no. ALD-1244) iCycler iQ TM (Bio-rad, cat. no. 170-8740) Bio-rad Tetrad® 2 Thermal Cycler (Bio-rad, cat. no. PTC-0240G with ALS-1296GC) NanoDrop 1000 Spectrophotometer (Thermo Scientific, cat. no. ND-1000) Bio-rad ChemiDoc XRS System (Bio-rad, cat. no. 170-8070) Immunofluorescence and Immunohistochemistry list-behavior=unordered prefix-word= mark-type=disc max-label-size=0 Olympus IX7 fluorescence microscope equipped with spinning disk confocal unit (Olympus) LSM Pascal 5 Carl Zeiss confocal microscope (Zeiss) Biochemical Extraction and Western Blot list-behavior=unordered prefix-word= mark-type=disc max-label-size=0 Hoefer Semi-Dry Transfer Unit (Hoefer, TE77) Molecular imager (Bio-rad, VersaDoc MP4000) Battery-operated spinning homogenizer (MIDSCI, cat. no. A0001) Ultracentrifuge tubes (Beckman Coulter, cat. no. 343778) Ultracentrifuge (Beckman, Optima TL Ultracentrifuge) SpeedVac (Thermo Scientific, cat. no. SPD111V) Savant RVT4104 refrigerated vapor trap with Savant SC110 SpeedVac (Savant) TEM list-behavior=unordered prefix-word= mark-type=disc max-label-size=0 JEOL JEM 1011 transmission electron microscope (JEOL) AMT digital imaging system (Advanced Microscopy Techniques) ELISA list-behavior=unordered prefix-word= mark-type=disc max-label-size=0 ELISA plate reader (Bio-Tek Synergy 2 microplate reader) LDH list-behavior=unordered prefix-word= mark-type=disc max-label-size=0 ELISA plate reader (Bio-Tek Synergy 2 microplate reader)

Article Title: A three-dimensional human neural cell culture model of Alzheimer’s disease
Article Snippet: Differential detergent extraction for WB The thick-layer 3D cultures of ReN cells were homogenized with TBS extraction buffer containing 50 mM Tris (pH 7.4), 150 mM NaCl, 1 mM NaVO 3 , 1 mM NaF, a protease inhibitor mixture (Roche Molecular Biochemicals), a phosphatase inhibitor cocktail (Thermo Scientific,), 2 mM PNT (EMD Millipore) and 1 mM Phenylmethylsulfonyl fluoride (PMSF, Sigma-Aldrich) by using battery-operated spinning homogenizer (MIDSCI, St. Louis, MO, USA).

Article Title: A 3D human neural cell culture system for modeling Alzheimer's disease
Article Snippet: 1121-3810, 1120-1810, 1120-8810 and 1126-7810, respectively) RNase-free microcentrifuge tubes (1.5 ml size; USA Scientific, cat. no. 1615-5500) PTC-200 thermal cycler (MJ Research, cat. no. ALD-1244) iCycler iQ (Bio-Rad, cat. no. 170-8740) Bio-Rad Tetrad 2 thermal cycler (Bio-Rad, cat. no. PTC-0240G with ALS-1296GC) NanoDrop 1000 spectrophotometer (Thermo Scientific, cat. no. ND-1000) Bio-Rad ChemiDoc XRS system (Bio-Rad, cat. no. 170-8070) IF and immunohistochemistry Olympus IX7 fluorescence microscope equipped with a spinning disk confocal unit (Olympus) LSM Pascal 5 Carl Zeiss confocal microscope (Zeiss) Biochemical extraction and western blotting Hoefer semi-dry transfer unit (Hoefer, TE77) Molecular imager (Bio-Rad, VersaDoc MP4000) Battery-operated spinning homogenizer (MIDSCI, cat. no. A0001) Ultracentrifuge tubes (Beckman Coulter, cat. no. 343778) • • • • • • • • • • • • • • • • • • • • • • • • Ultracentrifuge (Beckman, Optima TL ultracentrifuge) SpeedVac (Thermo Scientific, cat. no. SPD111V) Savant RVT4104 refrigerated vapor trap with Savant SC110 SpeedVac (Savant) TEM JEOL JEM 1011 transmission electron microscope (JEOL) AMT digital imaging system (Advanced Microscopy Techniques) ELISA ELISA plate reader (Bio-Tek Synergy 2 microplate reader powered by Gen5 analysis software) LDH ELISA plate reader (Bio-Tek Synergy 2 microplate reader powered by Gen5 analysis software) REAGENT SETUP Lentivirus We obtained the lentiviral polycistronic vectors (CSCW-IRES-GFP and CSCW-IRES-mCherry) from the Massachusetts General Hospital (MGH) viral core42, and these are available through the MGH viral core (https://vectorcore.mgh.harvard.edu).

Article Title: A three-dimensional human neural cell culture model of Alzheimer’s disease
Article Snippet: 3D-cultured cell pellets were homogenized in 1 volume of TBS extraction buffer containing 50 mM Tris (pH 7.4), 150 mM NaCl, 1 mM NaVO 3 , 1 mM NaF, a protease inhibitor mixture (Roche Molecular Biochemicals), a phosphatase inhibitor cocktail (Thermo Scientific), 2 mM PNT (EMD Millipore) and 1 mM PMSF (Sigma-Aldrich) by using battery-operated spinning homogenizer (MIDSCI).

Software:

Article Title: A 3D human neural cell culture system for modeling Alzheimer’s disease
Article Snippet: 1121-3810, 1120-1810, 1120-8810 and 1126-7810, respectively) RNase-free micro-centrifuge tubes (1.5 ml size; USA Scientific, cat. no. 1615-5500) PTC-200 Thermal Cycler (MJ Research, cat. no. ALD-1244) iCycler iQ TM (Bio-rad, cat. no. 170-8740) Bio-rad Tetrad® 2 Thermal Cycler (Bio-rad, cat. no. PTC-0240G with ALS-1296GC) NanoDrop 1000 Spectrophotometer (Thermo Scientific, cat. no. ND-1000) Bio-rad ChemiDoc XRS System (Bio-rad, cat. no. 170-8070) Immunofluorescence and Immunohistochemistry list-behavior=unordered prefix-word= mark-type=disc max-label-size=0 Olympus IX7 fluorescence microscope equipped with spinning disk confocal unit (Olympus) LSM Pascal 5 Carl Zeiss confocal microscope (Zeiss) Biochemical Extraction and Western Blot list-behavior=unordered prefix-word= mark-type=disc max-label-size=0 Hoefer Semi-Dry Transfer Unit (Hoefer, TE77) Molecular imager (Bio-rad, VersaDoc MP4000) Battery-operated spinning homogenizer (MIDSCI, cat. no. A0001) Ultracentrifuge tubes (Beckman Coulter, cat. no. 343778) Ultracentrifuge (Beckman, Optima TL Ultracentrifuge) SpeedVac (Thermo Scientific, cat. no. SPD111V) Savant RVT4104 refrigerated vapor trap with Savant SC110 SpeedVac (Savant) TEM list-behavior=unordered prefix-word= mark-type=disc max-label-size=0 JEOL JEM 1011 transmission electron microscope (JEOL) AMT digital imaging system (Advanced Microscopy Techniques) ELISA list-behavior=unordered prefix-word= mark-type=disc max-label-size=0 ELISA plate reader (Bio-Tek Synergy 2 microplate reader) LDH list-behavior=unordered prefix-word= mark-type=disc max-label-size=0 ELISA plate reader (Bio-Tek Synergy 2 microplate reader)

Article Title: A three-dimensional human neural cell culture model of Alzheimer’s disease
Article Snippet: Differential detergent extraction for WB The thick-layer 3D cultures of ReN cells were homogenized with TBS extraction buffer containing 50 mM Tris (pH 7.4), 150 mM NaCl, 1 mM NaVO 3 , 1 mM NaF, a protease inhibitor mixture (Roche Molecular Biochemicals), a phosphatase inhibitor cocktail (Thermo Scientific,), 2 mM PNT (EMD Millipore) and 1 mM Phenylmethylsulfonyl fluoride (PMSF, Sigma-Aldrich) by using battery-operated spinning homogenizer (MIDSCI, St. Louis, MO, USA).

Article Title: A 3D human neural cell culture system for modeling Alzheimer's disease
Article Snippet: 1121-3810, 1120-1810, 1120-8810 and 1126-7810, respectively) RNase-free microcentrifuge tubes (1.5 ml size; USA Scientific, cat. no. 1615-5500) PTC-200 thermal cycler (MJ Research, cat. no. ALD-1244) iCycler iQ (Bio-Rad, cat. no. 170-8740) Bio-Rad Tetrad 2 thermal cycler (Bio-Rad, cat. no. PTC-0240G with ALS-1296GC) NanoDrop 1000 spectrophotometer (Thermo Scientific, cat. no. ND-1000) Bio-Rad ChemiDoc XRS system (Bio-Rad, cat. no. 170-8070) IF and immunohistochemistry Olympus IX7 fluorescence microscope equipped with a spinning disk confocal unit (Olympus) LSM Pascal 5 Carl Zeiss confocal microscope (Zeiss) Biochemical extraction and western blotting Hoefer semi-dry transfer unit (Hoefer, TE77) Molecular imager (Bio-Rad, VersaDoc MP4000) Battery-operated spinning homogenizer (MIDSCI, cat. no. A0001) Ultracentrifuge tubes (Beckman Coulter, cat. no. 343778) • • • • • • • • • • • • • • • • • • • • • • • • Ultracentrifuge (Beckman, Optima TL ultracentrifuge) SpeedVac (Thermo Scientific, cat. no. SPD111V) Savant RVT4104 refrigerated vapor trap with Savant SC110 SpeedVac (Savant) TEM JEOL JEM 1011 transmission electron microscope (JEOL) AMT digital imaging system (Advanced Microscopy Techniques) ELISA ELISA plate reader (Bio-Tek Synergy 2 microplate reader powered by Gen5 analysis software) LDH ELISA plate reader (Bio-Tek Synergy 2 microplate reader powered by Gen5 analysis software) REAGENT SETUP Lentivirus We obtained the lentiviral polycistronic vectors (CSCW-IRES-GFP and CSCW-IRES-mCherry) from the Massachusetts General Hospital (MGH) viral core42, and these are available through the MGH viral core (https://vectorcore.mgh.harvard.edu).

Article Title: A three-dimensional human neural cell culture model of Alzheimer’s disease
Article Snippet: 3D-cultured cell pellets were homogenized in 1 volume of TBS extraction buffer containing 50 mM Tris (pH 7.4), 150 mM NaCl, 1 mM NaVO 3 , 1 mM NaF, a protease inhibitor mixture (Roche Molecular Biochemicals), a phosphatase inhibitor cocktail (Thermo Scientific), 2 mM PNT (EMD Millipore) and 1 mM PMSF (Sigma-Aldrich) by using battery-operated spinning homogenizer (MIDSCI).

Protease Inhibitor:

Article Title: A 3D human neural cell culture system for modeling Alzheimer’s disease
Article Snippet: 1121-3810, 1120-1810, 1120-8810 and 1126-7810, respectively) RNase-free micro-centrifuge tubes (1.5 ml size; USA Scientific, cat. no. 1615-5500) PTC-200 Thermal Cycler (MJ Research, cat. no. ALD-1244) iCycler iQ TM (Bio-rad, cat. no. 170-8740) Bio-rad Tetrad® 2 Thermal Cycler (Bio-rad, cat. no. PTC-0240G with ALS-1296GC) NanoDrop 1000 Spectrophotometer (Thermo Scientific, cat. no. ND-1000) Bio-rad ChemiDoc XRS System (Bio-rad, cat. no. 170-8070) Immunofluorescence and Immunohistochemistry list-behavior=unordered prefix-word= mark-type=disc max-label-size=0 Olympus IX7 fluorescence microscope equipped with spinning disk confocal unit (Olympus) LSM Pascal 5 Carl Zeiss confocal microscope (Zeiss) Biochemical Extraction and Western Blot list-behavior=unordered prefix-word= mark-type=disc max-label-size=0 Hoefer Semi-Dry Transfer Unit (Hoefer, TE77) Molecular imager (Bio-rad, VersaDoc MP4000) Battery-operated spinning homogenizer (MIDSCI, cat. no. A0001) Ultracentrifuge tubes (Beckman Coulter, cat. no. 343778) Ultracentrifuge (Beckman, Optima TL Ultracentrifuge) SpeedVac (Thermo Scientific, cat. no. SPD111V) Savant RVT4104 refrigerated vapor trap with Savant SC110 SpeedVac (Savant) TEM list-behavior=unordered prefix-word= mark-type=disc max-label-size=0 JEOL JEM 1011 transmission electron microscope (JEOL) AMT digital imaging system (Advanced Microscopy Techniques) ELISA list-behavior=unordered prefix-word= mark-type=disc max-label-size=0 ELISA plate reader (Bio-Tek Synergy 2 microplate reader) LDH list-behavior=unordered prefix-word= mark-type=disc max-label-size=0 ELISA plate reader (Bio-Tek Synergy 2 microplate reader)

Article Title: A three-dimensional human neural cell culture model of Alzheimer’s disease
Article Snippet: Differential detergent extraction for WB The thick-layer 3D cultures of ReN cells were homogenized with TBS extraction buffer containing 50 mM Tris (pH 7.4), 150 mM NaCl, 1 mM NaVO 3 , 1 mM NaF, a protease inhibitor mixture (Roche Molecular Biochemicals), a phosphatase inhibitor cocktail (Thermo Scientific,), 2 mM PNT (EMD Millipore) and 1 mM Phenylmethylsulfonyl fluoride (PMSF, Sigma-Aldrich) by using battery-operated spinning homogenizer (MIDSCI, St. Louis, MO, USA).

Article Title: A 3D human neural cell culture system for modeling Alzheimer's disease
Article Snippet: 1121-3810, 1120-1810, 1120-8810 and 1126-7810, respectively) RNase-free microcentrifuge tubes (1.5 ml size; USA Scientific, cat. no. 1615-5500) PTC-200 thermal cycler (MJ Research, cat. no. ALD-1244) iCycler iQ (Bio-Rad, cat. no. 170-8740) Bio-Rad Tetrad 2 thermal cycler (Bio-Rad, cat. no. PTC-0240G with ALS-1296GC) NanoDrop 1000 spectrophotometer (Thermo Scientific, cat. no. ND-1000) Bio-Rad ChemiDoc XRS system (Bio-Rad, cat. no. 170-8070) IF and immunohistochemistry Olympus IX7 fluorescence microscope equipped with a spinning disk confocal unit (Olympus) LSM Pascal 5 Carl Zeiss confocal microscope (Zeiss) Biochemical extraction and western blotting Hoefer semi-dry transfer unit (Hoefer, TE77) Molecular imager (Bio-Rad, VersaDoc MP4000) Battery-operated spinning homogenizer (MIDSCI, cat. no. A0001) Ultracentrifuge tubes (Beckman Coulter, cat. no. 343778) • • • • • • • • • • • • • • • • • • • • • • • • Ultracentrifuge (Beckman, Optima TL ultracentrifuge) SpeedVac (Thermo Scientific, cat. no. SPD111V) Savant RVT4104 refrigerated vapor trap with Savant SC110 SpeedVac (Savant) TEM JEOL JEM 1011 transmission electron microscope (JEOL) AMT digital imaging system (Advanced Microscopy Techniques) ELISA ELISA plate reader (Bio-Tek Synergy 2 microplate reader powered by Gen5 analysis software) LDH ELISA plate reader (Bio-Tek Synergy 2 microplate reader powered by Gen5 analysis software) REAGENT SETUP Lentivirus We obtained the lentiviral polycistronic vectors (CSCW-IRES-GFP and CSCW-IRES-mCherry) from the Massachusetts General Hospital (MGH) viral core42, and these are available through the MGH viral core (https://vectorcore.mgh.harvard.edu).

Article Title: A three-dimensional human neural cell culture model of Alzheimer’s disease
Article Snippet: 3D-cultured cell pellets were homogenized in 1 volume of TBS extraction buffer containing 50 mM Tris (pH 7.4), 150 mM NaCl, 1 mM NaVO 3 , 1 mM NaF, a protease inhibitor mixture (Roche Molecular Biochemicals), a phosphatase inhibitor cocktail (Thermo Scientific), 2 mM PNT (EMD Millipore) and 1 mM PMSF (Sigma-Aldrich) by using battery-operated spinning homogenizer (MIDSCI).



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MIDSCI Inc battery-operated spinning homogenizer
Battery Operated Spinning Homogenizer, supplied by MIDSCI Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/battery-operated+spinning+homogenizer/battery+operated+spinning+homogenizer/pmc04499058-283-106-108
Average 90 stars, based on 1 article reviews
battery-operated spinning homogenizer - by Bioz Stars, 2026-09
90/100 stars
  Buy from Supplier

90
MIDSCI Inc battery-operated spinning homogenizer midsci a0001
Battery Operated Spinning Homogenizer Midsci A0001, supplied by MIDSCI Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/battery-operated+spinning+homogenizer/battery+operated+spinning+homogenizer/pmc04499058-317-12-14
Average 90 stars, based on 1 article reviews
battery-operated spinning homogenizer midsci a0001 - by Bioz Stars, 2026-09
90/100 stars
  Buy from Supplier

96
Danaher Inc battery operated spinning homogenizer
Battery Operated Spinning Homogenizer, supplied by Danaher Inc, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/battery-operated+spinning+homogenizer/Thick-Walled+Polycarbonate+Tub/pm26068894-121-97-106
Average 96 stars, based on 1 article reviews
battery operated spinning homogenizer - by Bioz Stars, 2026-09
96/100 stars
  Buy from Supplier

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